Hereditary Cancers


Hereditary cancers account for ~5% of all malignancies and occur because of an inherited deleterious gene alteration from one of the parents. People carrying such alteration have a high risk of developing cancer at an early age, as well as developing multiple synchronous or metachronous cancers. Genetic screening of high-risk populations, such as individuals with a family history of cancer, is important in identifying cancer-related germline genetic variants and the chance of developing cancer in your lifetime, prompting early discovery of cancer lesions and improving patient survival. It also reveals genetic mutations that could be passed down to your children and their likelihood of getting cancer.


Peripheral blood

Oral swabs


Targets 208 genes associated with 37 types of inherited cancers  

Heriguard® comprehensively tests germline genetic alterations to thoroughly reveal hereditary risks in multiple cancer types (see table below). It could be used to screen high-risk populations for different cancer types, guide early diagnosis and prompt intervention before cancer occurs – all of which greatly improve treatment outcomes.  

  • Individuals with one or more immediate family member with a single or multiple primary malignant tumors 
  • Individuals with a family history of early onset of tumors, before the age of 50 
  • Individuals with rare malignant tumors, i.e. breast cancer in men 
  • Individuals with precancerous lesions or symptoms, i.e. inflammatory polyps, atypical breast hyperplasia  
  • Individuals who would like to know their hereditary risk of for developing cancer 

Hereditary Cancer Types

Bladder cancer   Breast cancer  Cholangiocarcinoma 
Colorectal cancer  Endometrial cancer*  Esophageal cancer 
Gastric cancer  Intestine cancer  Kidney cancer 
Leukemia  Liver cancer  Lung cancer 
Ovary cancer*  Testicular cancer#  Thyroid cancer  
Pancreatic cancer  Prostate cancer#   
*, female only cancers; #, male only cancers. 
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Identifies inherited predisposition to gastrointestinal (GI) cancer 

Heriguard® MMR reports germline genetic alterations in 24 genes, including mismatch repair (MMR) genes – a class of genes responsible for correcting mismatch errors that arise during DNA replication. The panel evaluates the hereditary risk of GI cancer while providing genetic evidence for diagnosing a series of hereditary cancer syndromes including hereditary non-polyposis colon cancer (HNPCC, also known as Lynch syndrome), MUTYH-associated polyposis, hereditary pancreatic cancer and hereditary gastric cancer among others.

  • Individuals with 10+ adenomatous polyps or 2+ hamartomatous polyps 
  • Individuals with one or more family members that have familial adenomatous polyposis (FAP) 
  • Individuals with one or more family members that have colorectal or endometrial cancer before the age of 50 
  • Individuals with two or more family members that has GI cancers at any age 
  • Individuals with family members diagnosed with tumor susceptibility syndrome or related tumors 


A comprehensive test for detecting germline alterations in 30 genes including BRCA1/2 genes 

Heriguard® BRCA detects germline single nucleotide variants (SNVs), insertions and deletions (indels), copy number variations (CNVs), and large genomic rearrangements (LGR) of 30 susceptible genes of breast and gynecologic cancers, including BRCA1/BRCA2 genes. By gaining early awareness of such mutations, it could effectively prevent the occurrence of cancer or achieve early diagnosis/treatment through routine screening.

  • High risk population of breast and gynecologic cancers
  • Healthy individuals seeking to understand their cancer risk


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